Robenidine hydrochloride
星期日, 十二月 27th, 2009Robenidine Hydrochoride
【Properties】 This product is white or light yellow crystalline powder, odorless, bitter taste; case of light color gradient depth. This product is slightly soluble in ethanol, very slightly soluble in chloroform, in water and ether, almost non-rong, slightly soluble in glacial acetic acid.
【Pharmacology】 Robenidine are Guanidine Derivatives. Has been widely used in poultry, rabbit coccidiosis prevention and treatment.
Robenidine mechanism of the anti-coccidia affecting the adenosine triphosphate interfere with protein metabolism coccidia.
Robenidine peak on the role of coccidia, mainly in the first-generation schizont stage 1, it can prevent the formation of merozoite schizonts. In addition, there were confirmed on the 2nd generation schizonts also inhibit, and even inhibit development of the role of egg sac.
【Uses】
(1) Poultry Robenidine has been widely used in our cooking chicken anti-coccidia drugs, 60mg/kg feed concentration on the tender, poisons, Brinell, giant, reactor type and ease the precocious Eimeria ball alone or mixed infection are have a good control effect. Of poisoning, and relaxation effects and Eimeria clopidol (125mg/kg) similar. Pairs of soft, pile type, giant, E.brunetti prevention is better than clopidol.
According to tests, the low drug feed concentration (30mg/kg) chickens, while not affecting the host immunity against coccidia, but the effect anticoccidial effect. Therefore, the outbreak of acute coccidiosis is still 60mg/kg drug feed concentration is appropriate.
(2) to avoid rabbits Robenidine addition to the role of intestinal Eimeria somewhat less, the right to avoid the majority of Eimeria (Eimeria, such as medium-sized, non-residual Eimeria, etc.) have a good control effect.
【Note】
(1) Since Robenidine have serious long-term continuous application of coccidia resistance, the majority of poultry farms have been disabled over a decade. Rational application of the proposed re-Robenidine, there may be a better anticoccidial effect.
(2) high feed concentration (60mg/kg) to chickens, can chicken, chicken livers, eggs, and even appear repulsive odor, but low feed concentration (30mg/kg) the above phenomenon does not occur. Trapped in this acute fulminant coccidiosis are advised to materials with high drug concentrations, 1 to 3 weeks after, and then be properly maintained at low concentrations.
(3) Some coccidia in the application when Robenidine, could continue to survive for 14 days, therefore, premature withdrawal, and often lead to recurrence of coccidiosis.
(4) The middle layer is disabled.
(5) Withdrawal period, poultry 5 days, the rabbit for 7 days.
【Usage and Dosage】 taken orally once per 1kg body weight the amount of poultry, rabbits 10 ~ 15mg
Robenidine hydrochloride mixed with feed premix feed, poultry 1 000kg for every 30 ~ 60g (active ingredient) in rabbits 100 ~ 150g (active ingredient)
【Specification】 agents and Robenidine hydrochloride tablets lOmg
Robenidine hydrochloride premix (1) 100g: 10g (2) 500g: 50g